Is Sorafenib a targeted drug?

Sorafenib is an oral targeted drug. Sorafenib, trade nameNEXavar, is a kinase inhibitor drug that has been approved for the treatment of primary renal cancer (advanced renal cell carcinoma) and advanced primary liver cancer (Hepatocellular carcinoma), FLT3-ITDpositiveAML and radioiodine-resistant advanced thyroid cancer.

Sorafenib is a protein kinase inhibitor active against many protein kinases, including VEGFR, PDGFR and RAFkinases. Among RAFkinases, sorafenib is more selective for c-Raf than B-RAF. Sorafenib treatment induces autophagy, thereby inhibiting tumor growth. Based on its 1,3- disubstituted urea structure, sorafenib is also a potent soluble epoxide hydrolase inhibitor, an activity that may reduce the severity of its side effects.

Sorafenib works by targeting a large number of serine/threonine and tyrosine kinases (RAF1, BRAF, VEGFR 1, 2, 3, PDGFR, KIT< /span>, FLT3, FGFR1 and RET) inhibit tumor cell proliferation and angiogenesis. Kinases are involved in tumor cell signaling, proliferation, angiogenesis, and apoptosis. Sorafenib inhibits Ras/mitogen-activated protein kinase(MAPK) multiple intracellular serines in the signal transduction pathway/Threonine kinase. Intracellular Rafserine/threonine kinase isoforms inhibited by sorafenib include Raf-1( or C-Raf), wild-type B-Raf and mutant B-Raf. Sorafenib inhibits cell surface tyrosine kinase receptors, such as KIT, FMS-like tyrosine kinase3 (FLT-3), RET, RET/PTC, vascular endothelial growth factor receptor-1 (VEGFR-1), VEGFR-2, VEGFR-3, and platelet-derived growth factor receptor-β (PDGFR-β). The retail price of Bangladesh Yaopin International Pharmaceutical 0.2g*120 tablets is about 700 yuan. The retail price of pharmaceuticals in Laos and ASEAN is about 0.2g*56 tablets500yuan. IndiaNATCOPharmaceutical retail price0.2g*120tablets1000yuan. If you want to get more high-quality information, you can contact YaDE. YaDE will do its best to learn more about high-quality overseas drugs for you.