Which class of anti-cancer drugs does Sorafenib belong to?

Sorafenibis a diaryl urea and an oral multi-kinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases related to tumor cell proliferation and tumor angiogenesis. Sorafenibis used to treat unresectable liver cancer, advanced renal cancer and differentiated thyroid cancer.

During early sorafenib treatment, the tumors gradually shrank. Before targeted therapy, the tumor size was 7.7cm× 7.9cm× 6.3cm. On the 5th week of targeted therapy, the tumor size decreased by 39.8%. On the 15 week of targeted therapy, the tumor size was reduced by 96.9%. According to an analysis of the SEER-Medicare database by Parikh and colleagues, patients treated with sorafenib had a median survival of 150.5 days compared with 62 days in the control group. The effect of sorafenib is relatively optimistic.

Sorafenib is a tablet that is usually taken twice daily with a glass of water. The patientshould accept no or only low-fat foods. High-fat foods may make sorafenib less effective. If the patient wants to eat high-fat food, take it at least 1 hour before or 2 hours after the meal. Sorafenib is an oral TKI that targets tumor angiogenesis and proliferation pathways by blocking vascular endothelial growth factor receptor (VEGFR)1–3, platelet-derived growth factor receptor(PDGFR)β-pathway and Raf-MEK-ERKsignaling. The retail price of Bangladesh Yaopin International Pharmaceutical is about 700 yuan for 0.2g*120 tablets. The retail price of pharmaceuticals in Laos and ASEAN is about 0.2g*56 tablets500yuan. IndiaNATCOPharmaceutical retail price0.2g*120tablets1000about 1000 yuan. If you want to get more high-quality information, you can contact YaDE. YaDE will do its best to learn more about high-quality overseas drugs for you.