What should I do if I become resistant to sotoraxib (AMG510)? Do you still need genetic testing?

KRAS G12C is one of the common driver mutations in non-small cell lung cancer. There have been no targeted drugs targeting the KRAS gene on the market before. Until 2021 , the launch of sotoraxibu (AMG510) filled this gap. Sotoracib is the first KRAS-targeted drug approved after nearly 40 years of research and is approved for the treatment of patients with KRAS. Targeted drugs for patients with locally advanced or metastatic non-small cell lung cancer(NSCLC) with G12Cmutations.

If the patient develops drug resistance, he should immediately consult the attending doctor. The doctor can promptly change the treatment plan or increase the dose according to the patient's condition, and whether genetic testing is needed according to the doctor's advice. The emergence of drug resistance is an unavoidable problem, but patients do not need to be anxious. In normal times, patients prolong the development of resistance to sotoraxib through certain methods. First of all, patients must strictly abide by the medication regulations and take the medication in strict accordance with the doctor's advice or recommended dosage in the instructions. If side effects occur, adjust the dose according to the doctor's advice and do not change the dose on your own. Secondly, patients should maintain a positive and optimistic attitude in daily life, exercise actively, develop good habits, and enhance their immunity. Finally, regular review and regular review according to the doctor's recommendations can detect drug resistance as soon as possible, so that the plan can be adjusted and the progression of the disease can be slowed down. The retail price of Everest Pharmaceuticals in Bangladesh120mg56tablets4more than a thousand, the retail price of Ziska Pharmaceuticals in Bangladesh120mg56tablets3More than a thousand, old The retail price of Laos Element Pharmaceuticals120mg56capsules4 is more than a thousand, and the retail price of Laos Lucius Pharmaceuticals120mg56capsules2000yuan. If you want to get more high-quality information, you can contact YaDE. YaDE will do its best to learn more about high-quality overseas drugs for you.