What kind of medicine is sotoracib (AMG510) and what are its side effects? .

Sotoracib (AMG510) is an inhibitor of the RAS GTP enzyme family, indicated for the treatment of FDA-approved trials in patients with KRAS Adult patients with G12C mutated locally advanced or metastatic non-small cell lung cancer (NSCLC) who have received at least one previous systemic therapy. Sotoracib blocks KRAS signaling, inhibits cell growth and promotes apoptosis in KRAS G12C tumor cell line. What are the side effects?

Adverse reactions of sotoraxib include lymphopenia (48%), hemoglobin reduction (43%), diarrhea (42%), increase in AST (39%), increased alanine aminotransferase (28%), musculoskeletal pain (35%), Decreased calcium(35%), Increased alkaline phosphatase(33%), Increased urinary protein(29%), Decreased sodium(28%), Nausea(26%), Fatigue(26%), Hepatotoxicity (25%), Albumin decrease(23%), Activated partial thromboplastin time(aPTT)Increase(23%), Cough(20%), Vomiting(17%), Constipation( 16%), dyspnea (16%), abdominal pain (15%), edema (15%), low appetite Depression(13%), arthralgia(12%), pneumonia(12%), skin rash(12%), etc.

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