What is the latest RMB price of mitotane? Can it be purchased in China?

Mitotane (Mitotane) is approved in the United States for chemotherapy of advanced adrenal cancer. It is available in 500 mg tablets under the brand name Lysodren. A typical initial dose is 2-6 grams per day, given in 3-4 divided doses, and the dose can be increased to achieve blood concentrations of 14-20 mg/L. Side effects of mitotane treatment are common and may include anorexia, nausea, vomiting, diarrhea, depression, dizziness, memory and concentration impairment, rash, gynecomastia, joint pain, and leukopenia.

Mitotane is an isomer ofDDT (dichlorodiphenyltrichloroethane), which was found to cause adrenal atrophy in dogs in animal studies and was later developed as an antineoplastic drug for advanced or metastatic adrenocortical cancer. Mitotane is directly cytotoxic to adrenal tissue and appears to act by inhibiting sterol-O-acyltransferase (SOAT) activity, which blocks the esterification of cholesterol. Cholesterol is the precursor of adrenocortical hormone, which accumulates in adrenocortical cells. Preventing esterification can lead to excess free cholesterol and other fatty acids that are toxic to hormone-producing adrenal cells.

The original drug of mitotane has been launched in China, but it has only been on the market for a short time, its purchase is very difficult, and it is not included in medical insurance. Mitotane marketed overseas The original drug has European and Turkish versions, specificationsThe price of 500mg*100 tablets per box may be more than 9,000 yuan (the price may fluctuate due to exchange rates). Mitotan generic drugs are also sold overseas, and their drug ingredients are basically the same as those of the original drug. For example, the specifications produced by Laos pharmaceutical factoriesThe price of 500mg*100 tablets per box may be more than 3,000 yuan (prices may fluctuate due to exchange rates).