How many pills of the new kidney cancer drug Lysodren mitotane should be taken a day?

Begin treatment with Mitotane. The recommended starting dose for adults is 2 to 3 grams per day, divided into two to three doses, taken with a meal containing fatty foods. A starting dose of 4 to 6 grams per day may be used in patients who need urgent control of Cushing's syndrome (a cluster of adrenal cancer symptoms caused by high hormone levels). There is limited information on the use of mitotane in children, but the recommended daily starting dose is 1.5-3.5 grams per square meter of body surface area (calculated based on the child's height and weight).

Doses are increased in increments until the"optimal" dose is reached that produces the best results without unacceptable side effects. If a patient experiences side effects, the dose may be reduced or treatment may be interrupted. Treatment should continue as long as there is benefit. If symptoms do not improve after three months of treatment at the optimal dose, treatment should be discontinued. Blood levels of the active substance should be monitored frequently, with a final target dose aiming to achieve blood levels of 14 to 20 mg per liter. This is usually achieved within three to five months. Levels above 20 mg/L may cause serious side effects but do not increase the drug's effectiveness.

The original drug of mitotane has been launched in China, but it has only been on the market for a short time, its purchase is very difficult, and it is not included in medical insurance. Mitotane marketed overseas The original drug has European and Turkish versions, specificationsThe price of 500mg*100 tablets per box may be more than 9,000 yuan (the price may fluctuate due to exchange rates). Mitotan generic drugs are also sold overseas, and their drug ingredients are basically the same as those of the original drug. For example, the specifications produced by Laos pharmaceutical factoriesThe price of 500mg*100 tablets per box may be more than 3,000 yuan (prices may fluctuate due to exchange rates).