Which company does Capmatinib come from?

Capmatinib is produced by Novartis and launched under the Tabrecta brand. It was launched in 20205, capmatinib received accelerated approval from the U.S. Food and Drug Administration for the treatment of patients with non-small cell lung cancer whose tumor mutations lead to mesenchymal epithelial transition (MET) exon 14 skipping.

Capmatinibcan cause interstitial lung disease (a group of lung diseases that cause scarring of lung tissue), pneumonitis (inflammation of lung tissue), hepatotoxicity (damage to liver cells), photosensitivity, and embryo-fetotoxicity. Based on clear positive signals from early laboratory studies of phototoxicity in cells, people may be more sensitive to sunlight and should be advised to take precautions to cover their skin, use sunscreen, and not tan while taking capmatinib.

atGEOMETRY Efficacy was demonstrated in the mono-1trial (NCT02414139), a multicenter, non-randomized, open-label, multi-short study enrolling334 participants with confirmedMETexon14 skipped metastatic non-small cell lung cancer. Some participants had previously received cancer treatment and some had not received treatment (naïve). Participants received capmatinib 400 mg orally twice daily until disease progression or unacceptable toxicity. The primary efficacy outcome measure was overall response rate (ORR), which reflects the percentage of participants whose tumors shrank by a certain amount. Another efficacy outcome measure is duration of response. The efficacy population included 28 participants who had never received treatment for NSCLC and 69 participants who had received prior treatment. 28 participants had an ORR of 68%, of which 4% had a complete response and 64% a partial response. 69 participants had an ORR of 41%, all had partial remission. Among responders who had never received treatment for NSCLC, 47% had a response duration of 12 months or longer, compared with 32.1% of responders who had received prior treatment. There are generic drugs that are officially on the market in Laos, and each box costs about 3 about 3,000. If you want to get more high-quality information, you can contact YaDE. YaDE will do its best to learn more about high-quality overseas drugs for you.

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