Does Eculizumab need to be used long-term?

Whether Eculizumab needs to be used long-term should be determined based on the doctor's diagnosis. Eculizumab is a recombinant human monoclonal antibody that inhibits terminal complement C5. This antibody has high affinity for C5, can block the formation of C5a and C5b-9, and protect mammalian cells from damage mediated by C5b-9, completely blocking complement-mediated destruction of blood cells.

Clinically used to treat rare blood diseases including paroxysmal nocturnal hemoglobinuria(PNH), atypical hemolytic uremic syndrome (aHUS), generalized myasthenia gravis (gMG), and neuromyelitis optica spectrum disorder (NMOSD). Some patients may require long-term use of eculizumab to maintain stable hemoglobin levels and renal function. Other patients may stop or reduce their medication after using it for a period of time to observe whether the condition recurs. In short, the use time of eculizumab should be determined by the doctor based on the patient's specific situation. The patient should take the drug according to the doctor's instructions, review it regularly, and provide timely feedback on the drug's effects and adverse reactions.

The generic drug Eculizumab has been launched in China and is covered by medical insurance. It is only available for reimbursement to eligible patients. The specification is 300mg (30ml) and the price per box may be more than 3,000 yuan. It is understood that the price of each box of the original Eculizumab drug sold overseas is more than 6,000 US dollars (the price may fluctuate due to the exchange rate). The ingredients of the original drug sold at home and abroad are basically the same, and the price of the original drug is still relatively expensive. There are currently no generic versions of eculizumab available on the market.