What is the typical duration of treatment with Axitinib/Axitinib?

Axitinib/Axitinib is a second-generation tyrosine kinase inhibitor. Axitinib/Axitinib and avelumab(bave ncio) or pembrolizumab (Keytruda) in combination to treat advanced renal cell carcinoma (RCC). The duration of treatment with axitinib was 6.15 months (range, 3.26-8.2 months). Patients were followed for a median of 13.5 months (range, 2.6-39.18 months) after starting axitinib. Most patients initiating axitinib therapy have significant disease burden.

Axitinib prevents cancer progression by inhibiting angiogenesis and preventing tumor growth. Axitinib selectively blocks the tyrosine kinase receptors VEGFR-1 (vascular endothelial growth factor receptor), VEGFR-2 and VEGFR-3. The plasma protein binding rate of axitinib is as high as 99%and most proteins are bound to albumin, followed by α1-acidic glycoprotein. Axitinib is primarily metabolized by the liver. CYP3A4 and CYP3A5 are the major liver enzymes, while CYP1A2 , CYP2C19 and UGT1A1 are minor. Axitinib was primarily eliminated unchanged in the feces (41%), of which 12% of the initial dose of axitinib was unchanged. A further 23% is eliminated in urine, most of which are metabolites. The half-life of axitinib ranges from 2.5 to 6.1 hours. The average clearance rate of axitinib is 38liters/hours. Overseas generic drugs are available in Bangladesh, and the retail price of Bikang Pharmaceutical in Bangladesh is about 5mg 60 tablets1800 yuan. If you want to get more high-quality information, you can contact Yaode, and Yaode will do its best to help you learn more about high-quality overseas drugs.