Which generation of targeted drugs is Brigatinib/Brigatinib?

Brigatinib/Brigatinib is the third generation of targeted drugs. Brigatinib/Brigatinib is used to treat ALKpositive, c-rosoncogene-1 pan>[ROS-1]-positive or epidermal growth factor receptor [EGFR] mutation-positive non-small cell lung cancer.

Control blood pressure before starting treatment. Measure fasting blood glucose concentrations before initiating treatment and initiate or optimize antihyperglycemic therapy as clinically indicated. Monitor blood pressure for 2 weeks after starting treatment and at least monthly thereafter. Monitor heart rate during treatment, more frequent monitoring may be necessary in patients receiving concomitant medications known to cause bradycardia. Monitor serum creatine kinase (CK, phosphocreatine kinase, CPK) and pancreatic enzyme (e.g., amylase, lipase) concentrations during treatment. Fasting blood glucose concentrations were measured regularly during treatment. Monitor for new or worsening respiratory symptoms, especially during the first week of treatment. Monitor for visual impairment.

Brigatinib is metabolized mainly by the CYPisoenzymes 2C8 and 3A4. P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP ) in vitro substrate:is not an organic anion transporter (OATP)1 B1, OATP1B3, organic anion transporter (OAT) 1, OAT3, organic cation transporter (OCT)1, OCT2, multidrug and toxin extrusion transporter (MATE)1, MATE2K or a substrate of the bile salt export pump (BSEP). In vitro, inhibits P-gp, BCRP, OCT1, MATE1 and MATE2K does not inhibit OATP1B1, OATP1B3, OAT1, OAT3, OCT2 or BSEP. Induction of CYP3A and possible induction of CYP2C isoenzymes by activation of the pregnaneX receptor (PXR). Brigatinib and its major metabolites do not inhibit CYPisoenzymes1A2, 2B6, 2C8 , 2C9, 2C19, 2D6 or 3A4/5. Generic drugs of this drug are produced in Laos and Bangladesh, and they are all officially marketed generic drugs. The retail price of Laos United Pharmaceuticals90mg30tablets900RMB, the retail price of pharmaceuticals in Laos and ASEAN90mg21tablets190 The retail price of Beacon Pharmaceutical in Bangladesh is around 090mg30tablets3200yuan, and the retail price of Yaopin International Pharmaceutical in Bangladesh is around 90mg30pills2200yuan. If you want to get more high-quality information, you can contact YaDE. YaDE will do its best to learn more about high-quality overseas drugs for you.

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