How much does brigatinib/brigatinib cost? Can it be reimbursed?

Brigatinib is a receptor tyrosine kinase inhibitor indicated for the treatment of adult patients with anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer in a U.S. Food and Drug Administration (FDA)-approved test. Brigatinib is already on the market in the country and can be reimbursed.

Generic drugs of this drug are produced in Laos and Bangladesh, and they are all officially marketed generic drugs. The retail price of Laos United Pharmaceuticals90mg30pills900 is about 1,000 yuan. The retail price of Laos and ASEAN pharmaceuticals is 90mg21pills1900 The retail price of Beacon Pharmaceutical in Bangladesh is about 90mg30pills3200yuan, and the retail price of Yaopin International Pharmaceutical in Bangladesh is about 90mg30pills2200yuan. Patients can choose drug versions based on their financial situation.

The elimination rates of brigatinib in feces and urine were 65% and 25% respectively. Looking at elimination from the two compartments, the unchanged rates of brigatinib in feces and urine were 41% and 86%, respectively. The steady-state half-life of brigatinib is 25 hours. Following oral administration of 180 mg brigatinib, the steady-state apparent oral clearance was 12.7 L/h. Treatment with brigatinib does not produce mutagenic chromosomal damage. Testicular toxicity, reported as reduced seminal vesicle and prostate weight, degeneration of testicular tubules, reduced testicular weight and size, and evidence of hypospermogenesis. Avoid eating grapefruit products, Grapefruit inhibitsCYP3Ametabolism, which may increase brigatinib serum concentrations. Avoid the use of St. John's wort, which induces CYP3A metabolism of brigatinib and may decrease serum concentrations. If you want to get more high-quality information, you can contact YaDE. YaDE will do its best to learn more about high-quality overseas drugs for you.

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