The difference between ixazomib and bortezomib

Ixazomib and bortezomib (Bortezomib) are two drugs used to treat multiple myeloma. The use and dosage of the drugs should be determined according to the guidance of the doctor. Patients should follow the doctor's advice and monitor regularly when using these drugs.

1. Chemical structure: Ixazomib is an imidazole proteasome inhibitor, while bortezomib is a boron-substituted triamine proteasome inhibitor. They have different chemical structures and therefore differences in molecular makeup.

2. Medication method: Ixazomib is administered orally and can be treated at home, making it convenient for patients to use. Bortezomib, on the other hand, is usually given as an intravenous injection and requires treatment in a hospital or clinic.

3. Mechanism of action: Both ixazomib and bortezomib inhibit the growth of multiple myeloma cells by inhibiting the function of the proteasome. However, their mechanisms of action are slightly different. Ixazomib interferes with proteasome function by selectively inhibiting the β5 subunit, while bortezomib works by binding to the β5 subunit in the proteasome and inhibiting its activity.

4. Usage: Ixazomib is usually used in the first-line treatment of multiple myeloma and can be used in combination with other drugs. Bortezomib is mostly used as a second-line treatment for multiple myeloma, or when other treatment options are ineffective.

The original drug of Ixazomib has been launched in China and is included in Class B medical insurance. The price of common capsule preparations may be more than 10,000 yuan per box, which is relatively expensive. The price of the original drug of ixazomib sold overseas is more than 10,000 US dollars per box (the price may fluctuate due to the exchange rate). Ixazomib Generic drugs are also produced and sold overseas, and their drug ingredients are basically the same as those of the original drugs sold domestically and abroad. For example, the price of 4mg*3 tablets produced by a Laos pharmaceutical factory may be less than 1,000 yuan per box (the price may fluctuate due to the exchange rate), and the price is relatively cheap.