The pharmacological effects of capmatinib

Capmatinib is a small molecule kinase inhibitor whose pharmacological effects are mainly based on the specific inhibition of MET kinase. METkinase is a receptor tyrosine kinase that participates in key processes such as cell growth, differentiation, migration and survival. In some cases, METkinase may be abnormally activated, leading to uncontrolled growth of cancer cells. Capmatinib exerts its pharmacological effects through the following mechanisms:

1. SpecificityMETkinase inhibition: Capmatinib blocks the abnormal activation of the METkinase signaling pathway by binding to METkinase and inhibiting its activity. This inhibitory effect is highly specific and mainly affects METkinase without affecting other kinases, allowing the drug to precisely target METkinase in cancer cells.

2. Inhibit cancer cell growth and division: METKinase plays an important role in cell growth and differentiation under normal circumstances, but when abnormally activated, it may lead to abnormal proliferation of cancer cells. The inhibitory effect of capmatinib slows down the proliferation and division of cancer cells, thereby blocking tumor growth.

3. Inhibits angiogenesis: METKinase is also involved in the process of angiogenesis and has a certain regulatory effect on the formation of new blood vessels. The inhibitory effect of capmatinib may reduce the blood supply of tumors and reduce the formation of new blood vessels, causing tumors to lack sufficient oxygen and nutrients, thereby affecting their growth.

4. Reduce tumor invasion and metastasis: METAbnormal activation of kinases is closely related to the invasion and metastasis of cancer cells. The inhibitory effect of capmatinib helps reduce the invasiveness of tumors into surrounding tissues and reduces the potential for metastasis.

Capmatinib is not currently available in China, so patients cannot purchase it domestically and need to purchase it through overseas channels. Currently, there are Hong Kong version of original drugs and foreign original drugs and generic drugs. The price of Hong Kong version of original drugs is about 35,000 yuan. The overseas original drugs are mainly European version of original drugs, and the price is more than 50,000 yuan, so original drugs are still relatively expensive. Generic drugs on the market abroad are much cheaper, mainly Laos generic drugs, the price is around 3,000 to 4,000 yuan, and the ingredients of original drugs and generic drugs are basically the same.