What are the side effects of Sparsentan?

sparsentanis an endothelin and angiotensinII receptor antagonist, used to reduce the risk of rapid disease progression in primary immunoglobulinA nephropathy(I gAN) Proteinuria in adults, usually urine protein to creatinine ratio (UPCR) ≥1.5g/g (1, 12.1). This indication received accelerated approval based on reduction in proteinuria. It has not been determined whether FILSPARI slows the decline in renal function in patients with IgAN. Continued approval for this indication may be contingent upon verification and characterization of clinical benefit in confirmatory clinical trials.

Common side effects of sparsentan include peripheral edema (14%) and hypotension, including orthostatic hypotension (14%) , Dizziness (13%), Hyperkalemia (13%), 1-10% Anemia (5%) , Acute kidney injury (4%) , Elevated transaminase (2.5%) etc.

Tell your doctor about all your current medications, Many drugs can affect sparsantine , especially: blood pressure or heart medications; diuretics or "water pills" that may increase blood potassium, such as spironolactone, Triamterene, amiloride; or non-steroidal anti-inflammatory drugs (NSAIDs)-Aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, etc. If you want to get more high-quality information, you can contact YaDE. YaDE will do its best to learn more about high-quality overseas drugs for you.