What are the precautions for taking sparsentan?

Sparsentan is used to reduce the level of protein in the urine (albuminuria) in patients with primary immunoglobulin A nephropathy (IgAN) who are at risk of rapid progression of the disease. The drug is only available under a restricted distribution program called the fils pari REMS (Risk Assessment and Mitigation Strategy) program.

Do not use this medicine with aliskiren (Tekturna) or other antihypertensive drugs (such as angiotensin receptor blockers, endothelin receptor blockers).

Using this drug during pregnancy can harm the fetus. If you are a woman who can become pregnant, your doctor will check to make sure you are not pregnant before starting the medication, during treatment, and 1 month after stopping the medication. Use an effective method of birth control to prevent pregnancy before starting, during treatment, and for 1 month after the last dose. If you think you are pregnant while taking this medicine, tell your doctor right away.

This medicine may cause serious liver problems. Check with your doctor right away if you have dark urine, fatigue, loss of appetite, nausea or vomiting, severe stomach pain, or yellowing of your eyes or skin.

Contact your doctor immediately if you experience blurred vision, confusion, dizziness, weakness, or lightheadedness when you stand up suddenly from a lying or sitting position, sweat, or are unusually tired or weak. These may be symptoms of low blood pressure.

This medicine may cause serious kidney problems. Check with your doctor right away if you develop agitation, coma, confusion, decreased urine output, depression, dizziness, headache, hostility, irritability, drowsiness, muscle twitching, nausea, rapid weight gain, seizures, coma, swelling of the face, ankles, or hands, or unusual fatigue or weakness.

Check with your doctor right away if you feel confused, have an irregular heartbeat, nausea or vomiting, nervousness, numbness or tingling in your hands, feet, or lips, stomach pain, difficulty breathing, or weakness or heaviness in your legs. These may be symptoms of hyperkalemia (high levels of potassium in the blood).

This medicine may cause fluid retention (excess water in the body). Check with your doctor right away if you experience decreased urine output, noises, rattling, or trouble breathing, swelling of the face, hands, feet, or lower legs, or weight gain.

Do not take other medications unless discussed with your doctor. This includes prescription or over-the-counter (OTC) medicines and herbal or vitamin supplements. If you want to get more high-quality information, you can contact Yao De, YaoDehui will do its best to learn more about high-quality overseas drugs for you.