What are the precautions for taking teriflunomide?

Teriflunomideis a pyrimidine synthesis inhibitor with anti-inflammatory and immunomodulatory properties. Teriflunomide is known as Marketed as Aubagio for the treatment of multiple sclerosis (ms), specifically relapsing forms of MS. The U.S. Food and Drug Administration (FDA) label provides an important warning about the risk of hepatotoxicity and teratogenicity in patients taking teriflunomide.

Using this drug during pregnancy can harm the fetus. Women will take a pregnancy test before starting to take this medication, use an effective method of birth control to prevent pregnancy during treatment and for 2 years after stopping treatment with this medication, tell your doctor right away if you become pregnant while taking this medication.

Teriflunomide may also cause birth defects if the father uses it while his sexual partner is pregnant, Men taking teriflunomide should use condoms as a form of birth control during sexual intercourse, Men who plan to be the father of a child should stop taking this drug and check with their doctor immediately.

Do not use this medicine with leflunomide (Arava). Using these drugs together may cause serious side effects. Consult your doctor right away if you have pain or tenderness in your upper abdomen, lighter stools, darker urine, loss of appetite, nausea, unusual fatigue or weakness, or yellowing of your eyes or skinThese may be symptoms of serious liver problems.

Teriflunomide can temporarily lower the number of white blood cells in the blood, increasing the chance of infection. It can also lower the number of platelets, which are necessary for normal blood clotting. If this happens, there are certain precautions you can take to reduce the risk of infection or bleeding, especially if the blood count is low.

If possible, avoid contact with infected people. Consult your doctor right away if you think you are infected or if you develop fever or chills, cough or hoarseness, lower back or side pain, or pain or difficulty urinating.

Check with your doctor right away if you notice any unusual bleeding or bruising, black, tarry stools, blood in your urine or stool, or red spots on your skin.

Be careful when using a regular toothbrush, floss, or toothpick. Your doctor, dentist, or nurse may recommend other ways to clean your teeth and gums. Please talk to your doctor before having any dental procedure.

Do not touch your eyes or the inside of your nose unless you have just washed your hands and have not touched anything else in the meantime.

Be careful not to cut yourself when using sharp objects such as safety razors or fingernail or toenail cutters.

Avoid contact sports or other situations where bruises or injuries may occur.

Before you start using this medicine, you need to have a tuberculosis skin test. Tell your doctor or anyone in your household if you have ever had a positive TB test.

While you are being treated with teriflunomide, stop use for at least 6 months and do not have any immunizations without your doctor's approval. Live virus vaccines should not be given while taking this medicine.

Using this drug may increase the risk of cancer, including blood cancers. If you are concerned about this risk, talk to your doctor.

If you experience burning, numbness, tingling, or pain in your arms, hands, legs, or feet, consult your doctor right away These may be symptoms of a condition called peripheral neuropathy.

This drug may cause serious allergic reactions, including anaphylaxis, which may be life-threatening and require immediate medical attention. Check with your doctor right away if you develop blistering, peeling or loose skin, red lesions, severe acne or rash, skin sores or sores, difficulty breathing, difficulty swallowing, fever or chills.

This drug may cause serious skin reactions (such as Stevens-Johnson syndrome, toxic epidermal necrolysis). Consult your doctor right away if you have black, tarry stools, blistered, peeling, or loose skin, chest pain, chills, cough, diarrhea, fever, itching, joint or muscle pain, red and swollen eyes, skin lesions (often purple), pain or difficulty urinating, sore throat, sores, white spots in the mouth or lips, swollen glands, unusual bleeding or bruising, or unusual fatigue or weakness.

Tell your doctor right away if your child develops fever, rash, swollen, painful or tender lymph nodes in the neck, armpits, or groin, unusual bleeding or bruising, or yellowing of the eyes or skin after using this medicine These may be symptoms of a serious, life-threatening illness called drug reaction with eosinophilia and systemic symptoms (DRESS).

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