Lao Element Pharmaceuticals’ lorlatinib contraindications

Lorlatinib is an inhibitor of multiple tyrosine kinases, including anaplastic lymphoma kinase (ALK) and c-rosoncogene-1 (ROS-1), lorlatinib is indicated for the treatment of adult patients with metastatic non-small cell lung cancer (NSCLC). What are the contraindications for taking lorlatinib from Laos Element Pharmaceuticals?

StrongCYP3AInducers:Contraindicated.

ModerateCYP3AInducers:Avoid coadministration. If coadministration cannot be avoided, increase the dose of lorlatinib.

PotentCYP3AInhibitors:Avoid coadministration. If concomitant use cannot be avoided, reduce the lorlatinib dose.

Fluconazole: Avoid concomitant use. If concomitant use cannot be avoided, reduce the lorlatinib dose.

CertainCYP3Asubstrates:Avoid coadministration with CYP3Asubstrates as minimal concentration changes may result in serious treatment failure.

CertainP-gpsubstrates:Avoid concurrent use with P-gpsubstrates as minimal concentration changes may result in serious treatment failure.

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