What are the side effects of Bangladesh Ziska Pharmaceuticals’ lorlatinib?

Lorlatinib/lorlatinib is an oral kinase inhibitor used to treat cancer. A kinase inhibitor is an enzyme inhibitor that blocks the action of protein kinases. Lorlatinib is used to treat certain types of non-small cell lung cancer (NSCLC) that have spread to other parts of the body. It is used only if the cancer has a specific genetic marker (the abnormal "ALK" gene). What are the side effects of Bangladesh Ziska Pharmaceuticals Lorlatinib?

Hematology: Very common (10%or more):Anemia (52%), thrombocytopenia (23%), lymphopenia (22%).

Musculoskeletal: Very common (10%or more):arthralgia(23%), myalgia/Musculoskeletal pain(17%), back pain(13%), limb pain(13%).

Visual: Very common (10%or more):Visual impairment (such as diplopia, photophobia, light sensitivity, blurred vision, reduced visual acuity, visual impairment, vitreous floaters) (15%).

Metabolism: Very common (10% or more):Hypercholesterolemia(96%), hypertriglyceridemia(90%), edema(Peripheral edema, eyelid edema, facial edema, generalized edema, localized edema, periorbital edema, peripheral swelling, swelling)(57%), hyperglycemia(52%), hypoalbuminemia(33%), weight gain(24%), lipase increase(24%), alkaline phosphatase increase(24%), increased amylase(22%), hypophosphatemia(21%)< /span>, hyperkalemia(21%), hypomagnesemia(21%), total cholesterol grade 3 or 4 (17%).

Psychiatry: Very common (10% or more):Cognitive effects(For example, amnesia, cognitive impairment, dementia, attention disorder, memory impairment, psychosis, attention deficit/Hyperactivity Disorders, confusion, delirium, disorientation, dyslexia)(29%), mood changes(24%), sleep changes(For example, abnormal dreams, insomnia, nightmares, sleep disorders, sleep talking, sleepwalking)(10%).

Common(1%to10%):Hallucinations, mental status changes(10%)

Liver: Very common (10%or above):with strongCYP450 3AWhen inducers are taken at the same time, ALT/ASTincreases4 grade(50%), and strongCYP450 3AWhen inducers are taken at the same time, ALT/AST increases 3 grade(33%)

Common (1% to 10%): ALT/ASTincreased 2 levels when taken concurrently with strong CYP450 3A inducers.

Respiratory system: Very common (10% or above):Difficulty breathing(27%), cough(18%), upper respiratory tract infection(such as fungal upper respiratory tract infection, viral upper respiratory tract infection)(12%).

Common (1% to10%):Interstitial lung disease(ILD), pneumonia.

Nervous system: Very common (10%or more):Peripheral neuropathy(eg, burning sensation, carpal tunnel syndrome, dysesthesia, ant walking, gait disturbance, hypoesthesia, muscle Weakness, neuralgia, peripheral neuropathy, neurotoxicity, paresthesias, peripheral sensory neuropathy, sensory disturbances)(47%), speech disorders(such as aphasia, dysarthria, speech delay)(14%).

Common (1% to10%):Attack.

Cardiovascular: Common (1% to10%):AV block, hypertension.

Dermatology: Very common (10% or more): Rash (eg, dermatitis acneiform, maculopapular rash, pruritic rash, rash) (14%). Others: Very common (10% or more): Weakness/Fatigue (26%), fever (12%).

The most common(20%or more)adverse reactions were edema, peripheral neuropathy, cognitive effects, dyspnea, cough, fatigue, weight gain, joint pain, mood effects, and diarrhea. The most common laboratory abnormalities are hypercholesterolemia, hypertriglyceridemia, anemia, hyperglycemia, elevated AST, hypoalbuminemia, and ALT.Elevated lipase, elevated alkaline phosphatase. The current retail price of generic drugs from 100mg30pills3 is about one thousand. If you want to get more high-quality information, you can contact YaDE. YaDE will do its best to learn more about overseas high-quality drugs for you.

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