What medicine does serputinib/serpatinib treat?

Selpercatinib/Selpercatinib is a small molecule tyrosine kinase inhibitor used to treat certain cancers caused by abnormal RET genes. Seputinib mainly targets tumors with RET gene mutations. RET gene mutations occur in a variety of cancers, such as non-small cell lung cancer, thyroid cancer, medullary thyroid cancer, etc.

Seputinib inhibits the activity of RET kinase, thereby blocking the growth and division of tumor cells, thereby achieving the effect of treating tumors. Seputinib capsules are administered orally, twice daily. Its use needs to be under the guidance of a doctor, and individualized treatment is required according to the patient's specific conditions. In addition, seputinib may cause some adverse reactions, such as edema, diarrhea, fatigue, dry mouth, high blood pressure, abdominal pain, constipation, rash, nausea and headache, etc. Patients need to pay close attention to their physical condition during use and communicate with their doctors in a timely manner.

Up to now, the original research drug is sold in China under the name of Seputinib, but it is not included in medical insurance. The price of each box of 80mg*56 tablets may be more than 10,000 yuan. There are European and American versions of the original drugs sold overseas, with the price of each box ranging from 20,000 to more than 100,000 yuan (prices may fluctuate due to exchange rates). Generic drugs of Seputinib have also been put on the market for sale overseas, and their pharmaceutical ingredients are basically the same as those of the original drugs sold domestically and abroad. For example, the price of 40mg*120 capsules produced by a Laos pharmaceutical factory is more than RMB 4,000 per box (the price may fluctuate due to exchange rates).