What is the dosage of serputinib/serpatinib?

Selpercatinib/Selpercatinib can be used to treat RET fusion-positive non-small cell lung cancer (NSCLC), RET-mutated medullary thyroid cancer (MTC), RET-fusion-positive thyroid cancer (TC), and other RET-fusion-positive solid tumors after approval. Doctors will select patients to receive seputinib based on the presence of RET gene fusions (NSCLC, TC or other solid tumors) or specific RET gene mutations (MTC) in tumor specimens.

Seputinib is available in capsule form and may be taken with or without food, unless taken with a proton pump inhibitor (PPI). If vomiting occurs after a dose, do not take another dose and continue until the next scheduled dose. The dose of seputinib is related to the patient's weight; 120 mg for patients less than 50 kg and 160 mg for patients 50 kg or more, taken orally twice daily (approximately every 12 hours) until disease progression or unacceptable toxicity occurs.

Up to now, the original research drug is sold in China under the name of Seputinib, but it is not included in medical insurance. The price of each box of 80mg*56 tablets may be more than 10,000 yuan. There are European and American versions of the original drugs sold overseas, with the price of each box ranging from 20,000 to more than 100,000 yuan (prices may fluctuate due to exchange rates). Generic drugs of Seputinib have also been put on the market for sale overseas, and their pharmaceutical ingredients are basically the same as those of the original drugs sold domestically and abroad. For example, the price of 40mg*120 capsules produced by a Laos pharmaceutical factory is more than RMB 4,000 per box (the price may fluctuate due to exchange rates).