The latest selling price of nivolumab in 2024

Nivolumab (Nivolumab) is an immune checkpoint inhibitor and a type of anti-cancer drug. It treats a variety of malignant tumors by regulating the immune system, including but not limited to advanced non-small cell lung cancer, melanoma, renal cell carcinoma, Hodgkin lymphoma, head and neck squamous cell carcinoma, etc.

Nivolumab is currently on the market in China and has been included in medical insurance. Patients can buy it domestically at a price of about four to five thousand yuan. For specific prices, please consult the local hospital pharmacy. The main ones abroad are Turkish original drugs, which cost around more than 2,000 yuan, and have the same ingredients and efficacy as the original drugs on the domestic market.

The mechanism of action is to activate and enhance the patient's own immune system by blocking the PD-1 (programmed death -1) receptor on the immune checkpoint. PD-1 is an immune checkpoint protein. Under normal circumstances, it can inhibit the activity of T cells to prevent overactive autoimmune reactions. However, some tumor cells can use the PD-1 pathway to evade immune system attack, preventing cancer cells from being cleared by the immune system. Nivolumab blocks the binding of PD-1 and its ligand PD-L1 (programmed death ligand -1), releasing the inhibition of T cells, allowing them to recognize, attack and eliminate cancer cells.

Nivolumab is usually given as an intravenous injection in a hospital or clinic by a medical professional. Clinical trials have shown that nivolumab shows significant efficacy in many cancer types, extending patient survival and improving quality of life. However, its use may be associated with some adverse reactions, such as fatigue, rash, digestive tract problems, etc. Therefore, during treatment with nivolumab, patients need to monitor closely and promptly report any discomfort symptoms to their doctors so that the treatment plan can be adjusted in a timely manner to ensure the safety and effectiveness of the treatment.