How long does it take for the side effects of Sotoracib (AMG510) to disappear?

Sotoracib (AMG510) is a targeted drug used to treat non-small cell lung cancer (NSCLC). Like other medications, it may cause side effects. The time it takes for side effects to disappear varies from person to person and depends on the individual's physiological condition and response to treatment. Sotoracib is a small molecule inhibitor of the KRAS G12C mutant protein found in up to 13% of refractory non-small cell lung cancer cases. During treatment with sotoraxib, serum aminotransferase elevations are common, and a subset of patients develop clinically apparent liver injury, which may be severe.

In clinical studies, the most common adverse reactions were diarrhea, musculoskeletal pain, nausea, fatigue, hepatotoxicity, and cough; the most common laboratory abnormalities were lymphopenia, decreased hemoglobin, increased aspartate aminotransferaseAST, increased alanine aminotransferase ALT, decreased calcium, increased alkaline phosphatase, increased urinary protein, and decreased sodium. Serious adverse reactions occurred in 50% of patients treated with the drug, including pneumonitis, hepatotoxicity, and diarrhea; the most common serious (Grade 3 or worse) adverse reactions were increased ALT, increased AST, and diarrhea. Fatal adverse reactions include respiratory failure, pneumonia, cardiac arrest, heart failure, gastric ulcer, and pneumonia. 9% of patients permanently discontinued treatment due to adverse reactions; adverse reactions leading to permanent discontinuation of treatment included hepatotoxicity, ALT elevation, AST elevation, and drug-induced liver injury.

If you are receiving this medication and experience side effects, please speak to your doctor who can assess symptoms and provide appropriate advice and support. At the same time, pay attention to maintaining good living habits and following the doctor's instructions to promote the side effects to subside as soon as possible.