Osimertinib mesylate/osimertinib complete instructions

1. Drug name: Methanesulfonic acid Osimertinib/osimertinib

2. Main ingredients: Methanesulfonic acidOsimertinib/Osimertinib（Osimertinib）

3. Pharmacological effects: mesylateOsimertinib/Osimertinib is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor. It blocks growth signaling in EGFRmutant non-small cell lung cancer (NSCLC) cells by inhibiting EGFRkinase activity.

IV. Indications: mesylateOsimertinib/Osimertinib is suitable for patients with EGFR T790Mpositive late-stage NSCLC.

5. Usage and dosage:

1.Adults: Orally, once a day, 80 mg each time.

2.Taking time: It can be taken with a meal or on an empty stomach.

6. Adverse reactions:

1.Common adverse reactions include rash, diarrhea, drowsiness, fatigue, cough, dyspnea, arrhythmia, hypertension, etc.

2.Serious adverse reactions include interstitial lung disease, retinal detachment, liver function damage, etc. Immediate medical attention is required.

7. Contraindications:

1.Those who are allergic to methanesulfonic acidosimertinib/osimertinib or its ingredients.

2.Pregnant and lactating women.

8. Notes:

1.Regularly monitor electrocardiogram, liver function, kidney function and other biochemical indicators during treatment.

2.Avoid simultaneous use withCYP3A4 inducers or inhibitors to avoid affecting drug efficacy or increasing adverse reactions.

3.When patients develop severe rash, difficulty breathing, visual problems and other symptoms, they should stop taking the medicine immediately and seek medical treatment.

9. Drug interactions:

1.Methanesulfonic acidOsimertinib/Osimertinib can affect the metabolism of other drugs by inhibiting CYP3A4 enzyme, so it should be used with caution.

2.Concurrent use with CYP3A4 inducers or inhibitors may increase the plasma concentration of the drug, and the dose needs to be adjusted.

10. Drug overdose:

1.If symptoms of drug overdose occur, seek medical attention immediately and provide supportive treatment.

2.Methods to treat overdose symptoms include gastric lavage, fluid rehydration, symptomatic treatment, etc.

11. Storage:

1.Please store in a cool and dry place away from direct sunlight.

2.Please keep medicines out of reach of children.

12. Availability and price :Osimertinib/The original drug of Osimertinib is currently on the market in China and has also been included in the medical insurance system. Domestic patients can easily purchase it. Its domestic selling price remains in the range of three to four thousand yuan, but for specific prices and medical insurance reimbursement details, patients are advised to consult their local hospital pharmacy to obtain the most accurate information. In comparison, the prices of foreign generic drugs are more affordable, especially those listed in Laos and Bangladesh. Most of them cost only a few hundred yuan, which is significantly lower than the domestic price. It is worth mentioning that the ingredients of these generic drugs are basically the same as those of the original drugs.

13. Manufacturer: AstraZeneca Pharmaceutical Company.

14. Notes:

1.This instruction manual is for reference only. Please follow your doctor’s advice for specific medication.

2.If you have any adverse reactions or questions, please consult your doctor or pharmacist.

The above is the complete instructions for osimertinib mesylate/osimertinib. Please read it carefully and follow your doctor's instructions when using it.