Seleniso drug prices in 2024

Selinexor (Selinexor) is a first-in-class, selective oral nuclear transport inhibitor that has been approved by the U.S. Food and Drug Administration (FDA) for use with low-dose dexamethasone (< span>Dexamethasone)In combination with the treatment of adult patients with relapsed/refractory multiple myeloma (RRMM) who have received at least four prior therapies and whose disease is responsive to at least two proteasome inhibitors, two immunomodulators, and an anti-CD38 monoclonal antibody.

The efficacy and safety of selinesol in RRMM was demonstrated inSTORM (Selinesol in Refractory Myeloma) Phase 2b trial. Briefly, the primary endpoint was overall response, defined as partial response or better, which was observed in 26% of patients. Among all responders, the median duration of response was 4.4 months. In the modified intention-to-treat (mITT) population, median overall survival was 8.6 months. The most common adverse events were thrombocytopenia, nausea, fatigue, anemia, decreased appetite, and weight loss, which were controlled with supportive care and dose adjustment.

The original drug Seleniso has been launched in China and has been included in the scope of medical insurance. The price of each box may be more than more than 20,000 yuan. Patients who meet the indications can be reimbursed by medical insurance. Currently, there is an American version of the original Seleniso drug sold overseas. The price of each box of 20mg*8 tablets may be more than 100,000 yuan (the price may fluctuate due to the exchange rate), which is very expensive. There are also generic Selinisol drugs on the market for sale overseas, and their drug ingredients are basically the same as those of the original drugs sold domestically and abroad. For example, the price of a box of 20mg*32 tablets produced by a Laos pharmaceutical factory may be more than 2,000 yuan (the price may fluctuate due to exchange rates).