How long does one box of neratinib/neratinib last and how much does it cost?

Neratinib/Neratinib is a kinase inhibitor that can be used alone or in combination with other drugs to treat human epidermal growth factor receptor 2 (HER2)-positive breast cancer. Neratinib works by irreversibly binding to and inhibiting specific receptors called HER2, HER4 and EGFR receptors, which are found in abnormally high numbers on the surface of cancer cells. These receptors receive signals that tell the cancer to grow and spread. Neratinib inhibits their ability and prevents HER2-positive breast cancer cells from growing and multiplying.

Neratinib is usually taken as a single dose of 240 mg, for early-stage Her-2-positive breast cancer, it is given once daily for one year, unless the breast cancer relapses. For advanced or metastatic breast cancer, capecitabine is given every day of a 21-day cycle (capecitabine is given on cycle days 1-14) as long as the cancer has not progressed and side effects are tolerated. Neratinib immediate-release oral film-coated tablets contain 40 mg of neratinib, which is equivalent to 48.31 mg of neratinib maleate. The common specification of neratinib currently on the market is 40mg*180 tablets per box. According to its prescription information, it takes a patient one month (30 days) to take one box, provided that the patient does not stop taking the medication due to other factors.

The original drug Neratinib is already on the market and is covered by medical insurance. The price of each box may be around RMB 7,000. The price of each box of the original drug Neratinib marketed overseas may be more than 10,000 US dollars, which is even more expensive. Generic drugs of neratinib are currently sold overseas, and their drug ingredients are basically the same as those of the original drugs sold domestically and abroad. For example, the price of each box produced by Bangladesh Yaopin International may be around 2,000 yuan (the price may fluctuate due to the exchange rate), and the price is relatively cheap.