Which hospital has obeticholic acid?

Obeticholic acid (Obeticholic acid) is an innovative drug mainly used to treat specific liver diseases. It is a farnesoid X receptor agonist. By activating this receptor, it can indirectly inhibit the expression of cytochrome genes, thereby inhibiting the synthesis of cholic acid. This mechanism of action allows obeticholic acid to exhibit significant effects in the treatment of diseases such as primary biliary cirrhosis and non-alcoholic fatty liver disease.

Obeeticholic acid is available in tablets (5 and 10 mg), available by prescription only. Depending on the patient's degree of liver impairment (which should be determined before initiating treatment), the recommended starting dose is 5 mg once daily or 5 mg once weekly. After a few months, if obeticholic acid is well tolerated, the dose can be increased. For patients who develop intolerable itching (a possible side effect of obeticholic acid), the dose may be reduced or treatment may be discontinued.

However, the current listing status of obeticholic acid in China is unclear. It is understood that the original drug of this drug has not been approved by the State Food and Drug Administration, so this drug is not yet sold in domestic hospitals and pharmacies. This is depressing news for patients who are in dire need of obeticholic acid.

It is worth noting that obeticholic acid has been sold overseas in many countries. The common specifications are 5mg*30 tablets and 10mg*30 tablets. The price of each box may be more than 9,000 US dollars. Generic drugs of obeticholic acid are already on the market overseas, and their ingredients are basically the same as those of the original drug. The price per box even ranges from a few hundred to 1,000 yuan (the price may fluctuate due to the exchange rate), which is relatively cheap compared to the price of the original drug.