Quick Look: Latest Prices of Brigatinib/Brigatinib in 2024

Brigatinib is a prescription drug used to treat adults with non-small cell lung cancer (NSCLC), including cancers that have a certain type of abnormal anaplastic lymphoma kinase (ALK) gene and that have spread to other parts of the body. It's unclear whether brigatinib is safe and effective in children.

Brigatinib is a tyrosine kinase inhibitor with activity against multiple kinases, includingALK, ROS1, insulin-like growth factor 1 receptor, and activity against EGFR deletions and point mutations. Brigatinib inhibits the proliferation and in vitro viability of cells expressing fusion proteinEML4-ALK and 17 crizotinib-resistant ALK mutants. Its effect extends to cells expressing EGFR deletion, ROS1-L2026M, FLT3-F691L and FLT3-D835Y. In a mouse EML4-ALK xenograft model, brigatinib had a dose-dependent inhibitory effect on tumor growth, tumor burden, and prolonged survival. The time course and exposure-response studies of brigatinib are unclear.

The original drug of brigatinib has been officially launched in China and has been included in the Class B medical insurance drug catalog. Its common packaging specifications include 30mg 14 tablets and 2 plates, 90mg 7 tablets and 4 plates, 90mg 7 tablets and 180mg 7 tablets and 4 plates. However, the price of each box of medicines may be as high as about 10,000 yuan, which does seem a bit expensive. Fortunately, relatively affordable generic versions of brigatinib are available in overseas markets. The pharmaceutical ingredients of these generic drugs are almost identical to the original drugs sold at home and abroad. For example, the price of a box of 90mg 30-tablet generic drugs produced by a Bangladeshi pharmaceutical factory is about RMB 2,000 (please note that the price may fluctuate due to exchange rate changes).