Patient instructions for the targeted drug osimertinib mesylate (Tagrisso) for the treatment of lung cancer

1.Drug name and indications:

Drug name: Osimertinib mesylate (Osimertinib)

Indications: Osimertinib mesylate is used to treat patients with non-small cell lung cancer (NSCLC), especially those with advanced NSCLC patients with epidermal growth factor receptor (EGFR) gene mutations.

2.Drug action mechanism:

Osimertinib mesylate is a third-generation EGFR inhibitor that inhibits the growth and proliferation of tumor cells by selectively inhibiting EGFR kinase activity and blocking the EGFR signaling pathway. It specifically targets the EGFR T790M mutation, one of the common EGFR resistance mutations, making osimertinib an effective drug for treating drug-resistant NSCLC.

3.Dosage form and dosage:

Dosage form: tablet (oral)

Regular dosage: In general, the recommended dosage for adult patients is 80 mg (mg) taken once a day, preferably at the same time.

4.Medication method:

Osimertinib mesylate should be swallowed whole, and preferably after meals to reduce the occurrence of gastrointestinal adverse reactions. Patients should follow their doctor's or pharmacist's advice and take the prescribed medication usage and dosage.

5.Notes:

Osimertinib mesylate may interact with other drugs, so patients should tell their doctor about all the medications they are taking, including prescription drugs, over-the-counter drugs, supplements, and herbal medicines, before taking this medicine.

Patients should regularly undergo blood tests, liver function tests, electrocardiograms and other related examinations during the medication period to monitor the efficacy and adverse reactions of the drug.

During the medication period, patients may experience some adverse reactions, such as rash, diarrhea, fatigue, etc. If any uncomfortable symptoms occur, the patient should inform the doctor in time so that the treatment plan can be processed and adjusted in time.

6.Adverse reactions and treatment:

Skin rash: If a mild rash occurs, patients can use mild cleansers and moisturizers to relieve symptoms. For severe rashes, anti-allergy medications or corticosteroids may be needed.

Diarrhea: Patients should increase fluid intake and avoid irritating foods and drinks. If diarrhea persists or worsens, patients should seek medical attention promptly.

Fatigue: Patients are advised to maintain adequate rest and arrange daily activities appropriately. If fatigue interferes with daily life, patients should discuss with their doctor that medication dosage adjustments or other measures may need to be taken.

Other adverse reactions: Patients should promptly inform their doctor of any discomfort or unusual symptoms for evaluation and treatment.

7.Pregnancy and lactation:

Osimertinib mesylate may cause harm to the fetus, so pregnant women should avoid contact with this drug. Women should take effective contraceptive measures while taking this medicine.

Because it is unknown whether osimertinib mesylate is excreted in breast milk, breastfeeding should be avoided while taking the drug.

8.Storage and processing:

Osimertinib mesylate should be stored in a cool, dry place away from children and pets.

Unused medicines should be disposed of properly and should not be discarded or dumped.

9.Emergency handling:

If patients experience serious adverse reactions or allergic reactions, such as difficulty breathing, laryngeal edema, severe rash, etc., they should seek medical treatment immediately and inform the doctor that they are using osimertinib mesylate.

10.Launch and Price

Osimertinib has now been launched in the domestic market and has been included in the medical insurance system. Patients can purchase it in pharmacies of major domestic hospitals. Its selling price is approximately between 4,000 and 5,000 yuan. However, the specific amount and detailed policies for medical insurance reimbursement will vary depending on the region. It is recommended that you consult the local hospital pharmacy for accurate information.

If you are looking for a more economical option, foreign generic drugs of osimertinib are a good choice, especially those from Laos and Bangladesh. They are affordable and cost only a few hundred yuan. They have a significant price advantage compared to domestic ones. More importantly, there is no significant difference in the pharmaceutical ingredients between these generic drugs and domestic original drugs.

The above is the medication instructions for patients with osimertinib mesylate in the treatment of lung cancer. Patients should read carefully and follow the instructions of their doctor or pharmacist before using this medicine. If they have any questions or discomfort, they should consult their doctor in time.