Can tucatinib/tucatinib be purchased in the country?

The original drug Tucatinib/Tucatinib is not on the domestic market, so patients in need cannot buy it in domestic hospitals and pharmacies. However, patients can obtain this drug through overseas channels and other channels, but they need to ensure the reliability and legality of the source. At the same time, the prices of different versions and specifications of tucatinib will vary.

Tucatinib is an investigational oral tyrosine kinase inhibitor that is highly selective for theHER2 kinase domain and has minimal inhibitory effects on the epidermal growth factor receptor, which may alter the toxicity profile. In a phase 1b dose-escalation trial, tucatinib combined with trastuzumab and capecitabine showed encouraging anti-tumor activity in patients with HER2-positive metastatic breast cancer, including those with brain metastases; targeting the inner domain of HER2 and the outer domain of trastuzumab simultaneously produced better survival outcomes than targeting the outer domain alone.

Most adverse events were mild related to diarrhea, nausea, palmar-plantar paresthesia syndrome, fatigue, and vomiting. Notable safety events include diarrhea controlled by short-term antidiarrheal medications and transient, reversible increases in liver enzyme levels.

Tucatinib is currently sold overseas in two forms: original drug and generic drug. Their drug ingredients are basically the same. The European version of the original drug is 150 mg and 60 tablets, and the price per box may be as high as more than 70,000 yuan (the specific price may be affected by exchange rate fluctuations); the Bangladeshi version of the 150 mg 30 tablet product may cost more than 4,000 yuan per box (the price may fluctuate due to exchange rate changes). For more information on overseas drug prices and related information, please consult Yaode Medical Consultants.