There are several manufacturers of palbociclib/palbociclib

Palbociclib is an important cancer drug used to treat locally advanced (has spread nearby) or metastatic (has spread to other parts of the body) breast cancer. Palbociclib can only be used if the cancer cells have receptors (targets) for certain hormones on their surface (HR positive) and do not produce abnormally large amounts of HER2 receptors (HER [human epidermal growth factor] negative). Currently, there are both original drugs and generic drugs on the domestic and foreign markets.

The original drug of palbociclib is developed and produced by Pfizer Inc. of the United States (Pfizer Inc.). The company is a world-renowned pharmaceutical company, and palbociclib is one of its important research and development achievements. In 2015, it was approved by the U.S. Food and Drug Administration (FDA) for the treatment of breast cancer. Their brand name is "Ibrance", which has been approved for marketing in many countries and is widely used in the treatment of breast cancer.

Palbociclib is an oral, first-in-class, highly selective cyclin-dependent kinase 4/6 inhibitor. The active substance palbociclib blocks the activity of cyclin-dependent kinase (CDK) 4 and 6. In some cancers, including HR-positive breast cancer, the activity of CDKs 4 and 6 is increased, which helps cancer cells multiply uncontrollably. By blocking CDK4 and CDK6, palbociclib slowed the growth of HR-positive breast cancer cells.

As the patent protection period of palbociclib gradually expires, many pharmaceutical companies have begun to produce generic versions of it. At present, domestic companies have also deployed domestic generic drugs of palbociclib, among which Qilu Pharmaceutical is the first company to obtain approval for the listing of generic drugs. In addition, Bangladesh Incepta Pharmaceuticals, Laos ASEAN Pharmaceuticals, Bangladesh Everest Pharmaceuticals and other pharmaceutical companies have also launched generic drugs of palbociclib. The price is more affordable than the original drug, but the drug ingredients are basically the same as the original drug.