Brief description of the instructions for giritinib

Giritinib is a targeted therapy for patients with FLT3 mutation-positive acute myeloid leukemia (AML). By inhibiting the activity of FLT3 kinase, giritinib can effectively control the progression of the disease and bring clinical benefits to patients. At present, this drug is widely used around the world. As a prescription drug, patients should strictly follow the doctor's instructions. This article is a brief description of the instructions for giritinib.

1. Usage and dosage

The recommended starting dose of giritinib is 120 mg (3 tablets × 40 mg tablets) once daily. Patients should take it at approximately the same time each day, with or on an empty stomach. Take with water. The medicine should be swallowed whole and should not be broken or crushed.

Treatment should be continued until the patient no longer has clinical benefit or until unacceptable toxicity occurs. Because clinical remission may be delayed, consideration should be given to continuing treatment at the prescribed dose for up to 6 months to ensure adequate time to achieve clinical remission.

2. Precautions and side effects

1.Hypokalemia or hypomagnesemia should be corrected before and during the use of giritinib, as these conditions may prolong the QT interval.

2.If the patient develops symptoms of posterior reversible encephalopathy syndrome, such as headache, disturbance of consciousness, seizures, or impaired vision, the drug should be discontinued immediately and a diagnosis should be made.

3.Giritinib may cause fetal damage. Pregnant women should understand the related risks before taking the drug and take effective contraceptive measures while taking the drug.

4.Giritinib may cause pancreatitis. If the patient develops symptoms of pancreatitis, treatment should be interrupted immediately and the dose should be reduced.

Common adverse reactions include myalgia/arthralgia, elevated transaminases, fatigue/ malaise, fever, non-infectious diarrhea, dyspnea, etc. However, not all patients will experience the above adverse reactions, which vary from person to person.

3. Storage conditions

Giritinib should be shielded from light, sealed, and stored at room temperature in a dry place. Avoid humid and high-temperature environments to ensure drug quality.

4. Price information

The price of giritinib varies depending on factors such as where the drug is produced, how it is purchased, and the quantity purchased. Generally speaking, the price of gilitinib in China is around 25,560 yuan per box. Please consult your local medical institution or pharmacy for specific prices. In addition, its generic medicines are also sold in Laos, each costing about two to four thousand, depending on the version and specifications. Patients should choose the appropriate version according to their own needs.

Please note that the above information is for reference only. The specific usage, dosage, precautions and price should be based on the advice of your doctor or pharmacist.