Giritinib drug use guide

Giritinib, as a targeted therapy for patients with FLT3 mutation-positive acute myeloid leukemia (AML), can effectively curb disease progression by specifically inhibiting FLT3 kinase activity and bring treatment hope to patients. The purpose of this article is to provide patients with detailed guidance on the use of giritinib.

1. Usage and dosage

The standard starting dose of giritinib is 120mg (i.e. 3 tablets × 40mg tablets), taken once daily. It is recommended that patients take the medicine at a fixed time every day, either with meals or on an empty stomach, with water. Make sure you swallow the tablet whole and do not break it or crush it. Treatment cycles need to be adjusted based on the patient's clinical response and tolerability. Generally, in the absence of disease progression or unacceptable side effects, it is recommended to continue treatment for at least 6 months to fully observe the drug's efficacy.

2. Medication precautions and side effects

1.Be sure to correct hypokalemia and hypomagnesemia before and during treatment with giritinib, as these electrolyte abnormalities may increase the risk of QT prolongation.

2.If the patient develops symptoms of posterior reversible encephalopathy syndrome such as headache, disturbance of consciousness, epileptic seizures or impaired vision, the drug should be discontinued immediately and seek medical attention.

3.Giritinib may have adverse effects on the fetus. Pregnant women should fully understand the related risks before using it and take effective contraceptive measures during treatment.

4.Giritinib may cause pancreatitis. If related symptoms occur, the drug should be discontinued immediately and the dose should be reduced.

5.Common adverse reactions include myalgia/arthralgia, elevated transaminases, fatigue/ malaise, fever, non-infectious diarrhea and dyspnea, etc. However, not every patient will experience the above reactions, which vary depending on individual differences.

3. Storage conditions

Please store gilitinib in a dry, cool place away from direct sunlight and moisture. Store in a sealed container to ensure drug quality.

4. Price information

The price of giritinib varies depending on factors such as the place of origin, purchase method and quantity of the drug. Generally speaking, the price of gilitinib in China is around 25,000 yuan per box. In addition, generic versions of giritinib are also available in Laos and other places. The price is relatively low, about RMB 2,000 to RMB 4,000. The specific price varies depending on the version and specifications. Patients are asked to choose the appropriate version based on their own financial conditions and needs.

Please note that the above information is for reference only. The specific usage, dosage, precautions and price should be based on the advice of your doctor or pharmacist. While using giritinib, please maintain communication with your doctor to ensure the effectiveness and safety of the treatment.