Why does Japanese troagliptin emphasize taking it after meals?

Trelagliptin (Trelagliptin) is a new dipeptidyl peptidase-4 (DPP-4) inhibitor oral drug developed and produced by a Japanese company. Compared with other anti-diabetic drugs, it is emphasized to be taken after meals for the following reasons:

1. Improve drug absorption: Tretagliptin is absorbed slowly on an empty stomach, but taking it after meals can improve its bioavailability and drug absorption speed. Eating after meals can promote intestinal peristalsis and gastric juice secretion, allowing the drug to be better dissolved and quickly absorbed into the blood. This way of taking can improve the effectiveness of the drug.

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2. Control blood sugar peaks: Taking trotagliptin after meals can better control blood sugar peaks. After a meal, when the body digests and absorbs food, the blood sugar concentration will increase. As a blood sugar regulator, trotagliptin can reduce the degradation of insulin when insulin is released by inhibiting the activity of DPP-4 enzyme, thereby slowing down the rise of blood sugar, making blood sugar peaks gentler, and reducing the need for insulin.

3. Reduce gastrointestinal adverse reactions: Taking trotagliptin after meals can reduce the occurrence of gastrointestinal adverse reactions. Common adverse reactions of trotagliptin include nausea, vomiting, diarrhea and other digestive system-related problems. Taking it after meals can reduce the severity of these adverse reactions and improve patient tolerance.

In general, Japan’s troagliptin emphasizes taking it after meals to improve the absorption of the drug, better control blood sugar peaks, and reduce the occurrence of gastrointestinal adverse reactions. This medication is designed to help people with diabetes better manage their blood sugar and improve their quality of life. Of course, before using tretagliptin, patients should consult their doctor and follow the doctor's recommendations to ensure safety and effectiveness.