How much does a box of authentic Crizotinib/Xalkori cost?

Crizotinib/Crizotinib is an anti-cancer drug used to treat non-small cell lung cancer (NSCLC), with the trade name Xalkori. Crizotinib inhibits the c-Met/hepatocyte growth factor receptor (HGFR) tyrosine kinase, which has been implicated in the development of many other histological forms of malignancy. It also acts as an ALK (anaplastic lymphoma kinase) and ROS 1 (c-ROS oncogene 1) inhibitor. Crizotinib is also indicated for the treatment of unresectable, relapsed or refractory inflammatory anaplastic lymphoma kinase (ALK)-positive myofibroblastic tumor (IMT) and anaplastic large cell lymphoma (ALCL).

In"ALK-positive" or "ROS1-positive" tumors, the ALK or ROS1 protein is abnormally active, which can promote uncontrolled growth of cells and the development of new blood vessels that supply the cells. The active substance in crizotinib is an RTK inhibitor. It works primarily by blocking the activity of ALK or ROS1, including when genetic changes are present, thereby reducing the growth and spread of cancer in ALK-positive anaplastic large cell lymphomaand myofibroblastoma and inALK- and ROS1-positive non-small cell lung cancer.

Crizotinib, this original drug is sold in China as Crizotinib capsules (trade name: XALKORI/XALKORI), and has been included in medical insurance, and its price is usually high. It is available in two packaging specifications: 250 mg 60 capsules and 200 mg 60 capsules. The market price may exceed 10,000 yuan per box. Fortunately, for patients who meet the indications, national medical insurance can provide reimbursement. Overseas, the price of the original crizotinib drug is approximately more than 10,000 yuan per box, but the actual price may be affected by exchange rate fluctuations.