How much does a box of Apelvis produced by Novartis cost in 2024?

Alpelisib (Alpelisib) is a drug made by Novartis and belongs to a class of drugs called PI3K inhibitors. Its main function is to inhibit the activity of an enzyme called PI3K in human cells. PI3K enzyme plays an important regulatory role in cells and participates in a variety of signaling pathways, including cell growth, proliferation, and survival.

Apelix is mainly used to treat a specific type of breast cancer, namely HER2-negative advanced or metastatic breast cancer with PIK3CA gene mutations. According to the results of clinical trials, apelvis showed advantages in extending progression-free survival compared with other treatments. However, there are some side effects and safety concerns with apelix. The most common adverse reactions include hyperglycemia, diarrhea, rash, nausea, fatigue, etc. Before using Apelvis, doctors need to evaluate the patient's genetic mutations and other related factors to determine whether the drug is suitable for use.

The original drug of Apellis has not yet been launched in the domestic market, so it has not been included in the medical insurance system, and the domestic price has not yet been determined. In overseas markets, the original Apelis drug has two versions, European and Indian. The European version may cost more than 40,000 yuan per box (150mg*56 tablets), while the Indian version (150mg*28 tablets) may cost more than 5,000 yuan per box (the price may change due to exchange rate fluctuations). In addition, generic Apelvis drugs have been produced overseas, and their drug ingredients are similar to the original drug. For example, the price of each box (150mg*28 tablets) produced by a Laos pharmaceutical factory may be about more than 2,000 yuan (the price may change due to exchange rate fluctuations).