What is fenelidone a drug that treats

Finerenone (Finerenone) is a nonsteroidal selective mineralocorticoid receptor antagonist (MRA) used to treat patients with chronic kidney disease (CKD) associated with type 2 diabetes (T2D). Fennelidone reduces the risk of persistent decline in estimated glomerular filtration rate (eGFR), renal failure, cardiovascular death, nonfatal myocardial infarction (MI), and heart failure hospitalization in adults with chronic kidney disease (CKD) associated with type 2 diabetes (T2D).

Fenelide works primarily by blocking excessive activation of the mineralocorticoid receptor (MR). Excessive activation of mineralocorticoid receptors is thought to lead to fibrosis and inflammation, leading to permanent renal structural damage.

Fenelidone tablets can be taken once daily with or without food. Common adverse reactions to fenelidone include hyperkalemia (high potassium levels), hypotension, and hyponatremia (low sodium levels). The label contains a warning and precaution that fenelidone can cause hyperkalemia and serum potassium levels should be monitored.

The original version of fenelidone tablets has been launched in China and has been included in the reimbursement scope of Class B medical insurance. Common specifications are10mg*14 tablets and 20mg*7 tablets. The price of each box may be several hundred yuan. The original version of fenelidone tablets listed overseas is relatively expensive. There are American, European and Japanese versions. The price of 100 tablets of the same specifications may be around 3,000 yuan (the price may fluctuate due to exchange rates). In addition, there are also generic drugs sold overseas. The ingredients of the two drugs are basically the same. For example, the price of 30 tablets produced by a Lao pharmaceutical factory may be around 200 yuan (the price may fluctuate due to the exchange rate).