What are the side effects of cabozantinib?

Caboozantinib is an anticancer drug that is available in two drug forms. The capsule form (Cometriq) is designed to treat medullary thyroid cancer, while the tablet form (Cabometyx) is used to treat renal cell carcinoma, hepatocellular carcinoma and differentiated thyroid cancer. Cometriq and Cabometyx brands have different formulations and are not interchangeable.

Get emergency medical help if you have signs of an allergic reaction while using cabozantinib: hives; trouble breathing; swelling of your face, lips, tongue, or throat.

Cabozantinib may cause a perforation (hole or tear) or fistula (abnormal passage) in the stomach or intestines. Call your doctor if you have severe stomach pain or if you feel like you are choking or gagging when you eat or drink.

Cabozantinib may cause serious side effects. Contact your doctor right away if you have: severe headache, blurred vision, severe shaking in your neck or ears; severe and persistent vomiting, diarrhea, or constipation; swelling of your hands, arms, legs, or feet; easy bruising or bleeding (nosebleeds, gum bleeding, heavy menstrual bleedingor any bleeding that doesn't stop); bloody or tarry stools, cough Bloody mucus or vomit that looks like coffee grounds; jaundice (yellowing of the skin or eyes); pain, blisters, bleeding, or severe rash on the palms or soles of the feet; confusion, thinking problems, weakness, vision changes, seizures; dizziness, like you might pass out; pain or numbness in the jaw, red and swollen gums, loose teeth, or slow healing after dental work; low Blood calcium - muscle spasms or contractions, numbness or tingling (around mouth, fingers and toes); low white blood cell count - fever, mouth sores, skin ulcers, sore throat, cough, difficulty breathing; Adrenal gland problems - nausea, vomiting, extreme Tiredness, dizziness, weakness, fainting; or signs of stroke or blood clots - sudden numbness or weakness on one side of your body, vision or balance problems, trouble speaking or understanding what others are saying to you, chest pain, trouble breathing, swelling or pain in your arms or legs.

Common side effects of cabozantinib may include: tiredness, moodiness, dry skin, thinning hair, decreased sweating, weight gain, facial puffiness, increased sensitivity to cold temperatures; stomach pain, nausea, vomiting, loss of appetite, diarrhea, constipation; pain, redness, swelling, or ulcers in the mouth or throat; difficulty speaking, change in taste; cold symptoms such as stuffy nose, sneezing, sore throat, cough; rash; muscle, bone, and joint pain; abnormal liver function tests or other blood tests; weight loss; or lightening of hair color. This is not a complete list of side effects, and other side effects may occur.

To sum up, the side effects of cabozantinib involve many aspects, including gastrointestinal reactions, skin reactions, systemic symptoms and other reactions. Patients should pay close attention to changes in their condition while receiving cabozantinib treatment and communicate with their doctors in a timely manner so that they can be properly handled. At the same time, doctors should also develop personalized treatment plans based on the patient's specific conditions to minimize the occurrence of side effects and improve treatment effects.