Seleniso China official website price

In the domestic market, the original brand drug Selinexor is already available, and it is also included in the scope of Class B medical insurance. However, only patients who meet specific indications can apply for reimbursement. This medicine usually comes in two packaging specifications: 20mg 12 tablets and 20mg 16 tablets. The price is about 20,000 yuan per box.

Selinisolby blocking exportin1 (xpo 1; also known as chromosomal region maintenance 1 [CRM1]) inhibits the nuclear export of macromolecules, including tumor suppressor proteins (e.g., p53), cell cycle regulatory proteins, and messenger ribonucleic acids (mRNAs) encoding oncogenic proteins (e.g., c-myc, cyclin D1); XPO1 overexpression is observed in multiple malignancies, including multiple myeloma, and is associated with poor prognosis in multiple myeloma. In preclinical studies, in vitro pro-apoptotic activity in multiple myeloma cell lines and patient tumor samples and anti-tumor activity in mouse xenograft models were demonstrated.

Selinisol is available as an oral tablet. Usually given once a week, rarely twice a week. Selinisol is often given in combination with the steroid tablet dexamethasone, or with the proteasome inhibitors bortezomib and dexamethasone. Selinesol tablets should be swallowed whole with water. Do not break, chew, or crush tablets.

In overseas markets, the price of American original drugs is much higher. A box of 8 tablets may sell for more than 100,000 yuan, and the price will fluctuate with the exchange rate. But the good news is that there are already generic drugs available overseas. These drugs have similar ingredients to the original drugs. For example, a 32-piece package of generic drugs produced in Laos costs only more than 2,000 yuan, but the price will also change with the exchange rate.