How to take Voranigo (Vorasidenib)

Voranigo (Vorasidenib) is indicated for the treatment of adult and pediatric patients aged 12 years and older with grade 2 astrocytoma or oligodendroglioma who are predisposed to isocitrate dehydrogenase-1 (IDH1) or isocitrate dehydrogenase-2 (IDH2) mutations after surgery, including biopsy, subtotal or total resection. Voranigo comes in tablet form and is administered as follows:

1. Before treatment: Before starting to take Voranigo, evaluate blood chemistry and liver laboratory tests; select patients with grade 2 astrocytoma or oligodendroglioma for treatment based on the presence of IDH1 or IDH2 mutations in tumor specimens.

2. Recommended dose: For adult patients, the recommended dose of Voranigo is 40 mg orally once daily until disease progression or unacceptable toxicity occurs. The recommended dose for pediatric patients 12 years and older is based on body weight. Patients ≥40 kg can take 40 mg orally once daily; patients <40 kg can take 20 mg orally once daily. Treatment should be continued until disease progression or unacceptable toxicity occurs.

3. Medication management: Swallow Voranigo tablets whole with or without food Do not split, crush or chew tablets.

4. Dosage adjustment: Adverse reactions may occur when using Voranigo. The doctor may adjust the drug dose according to the severity of the condition. The first dose may be reduced to 20 mg orally once a day; the second dose may be reduced to 10 mg orally once a day; if the patient cannot tolerate the lowest dose of 10 mg once a day, Voranigo needs to be discontinued.

5. Missed dose: Take Voranigo tablets at approximately the same time each day. If you miss a dose, take the missed dose as soon as possible within 6 hours. If a dose is missed by more than 6 hours, skip the missed dose and take the next dose at the scheduled time. If vomiting occurs after taking one dose, do not take a replacement dose and take the next dose at the scheduled time the next day.