How much does it cost to buy a box of Sparsentan/Sparsentan in 2024?

Sparsentan is used to reduce proteinuria (increased protein in the urine) in certain patients with primary immunoglobulin A (IgA) nephropathy. Sparsentane belongs to the endothelin and angiotensin II receptor antagonist class of drugs. It works by blocking endothelin and angiotensin II, two substances that play a role in the progression of kidney disease.

Spaxentan is available as an oral tablet. It is usually taken once daily before meals. Take spaxentan at about the same time each day and consistent with meal times, and do not eat more or less than prescribed by your doctor. Patients may swallow the tablets whole; do not split, chew, or crush them. Your doctor may start you on a low dose of sparsentane and increase the dose after 14 days. Spaxentan may control proteinuria in IgA nephropathy but does not cure it. Continue taking spaxentan even if you feel well. Do not stop taking spaxentan without consulting your doctor. Sparsentan may cause hypotension. Patients need to drink plenty of water while taking it to prevent blood pressure from falling too low.

The original drug of sparsentan has not yet been launched in the country, so its price is not yet clear. The drug has been on the market overseas for a short time. The common specifications are: 200mg*30 tablets and 400mg*30 tablets. The price of each box may exceed US$10,000 (the actual price will be different due to exchange rate fluctuations), and the overall cost is relatively expensive. It is understood that generic drugs of Sparsentan are also sold in overseas markets, and their ingredients are basically the same as those of the original drug. For example, the price of 400mg*30 tablets produced by a Lao pharmaceutical factory may be around 7,000 yuan per box (the price will also fluctuate due to the exchange rate).