How much does a box of olaparib/olaparib targeted drugs cost in 2024?

Olaparib (Olaparib) is a PARP inhibitor used to treat cancer of the breast, prostate, ovary, pancreas, fallopian tube, or peritoneum. Lynparza helps cancer cells repair themselves by blocking a protein called PARP. Blocking PARP causes cancer cells to die. Patients are often treated with Lynparza if their cancer has specific genetic markers, including BRAC1, BRCA2, HRR and HER2 negative. Doctors test patients for this gene. Lynparza is a tablet that is usually taken twice daily with or without food.

Olaparib is an inhibitor of poly(ADP-ribose) polymerase (PARP), including PARP1, PARP2 and PARP3. PARP enzymes are involved in normal cellular functions such as DNA transcription and DNA repair. Lynparza has been shown to inhibit the growth of selected tumor cell lines in vitro and reduce tumor growth in mouse xenograft models of human cancer, both as monotherapy and following platinum-based chemotherapy. Increased cytotoxicity and antitumor activity following olaparib treatment were observed in cell lines and mouse tumor models with deletion of BRCA1/2, ATM, or other genes involved in homologous recombination repair (HRR) of DNA damage and associated with platinum response.

Olaparib’s original drug has been launched in the domestic market and is included in Class B medical insurance, but it is only applicable to patients with specific indications. Its common specifications include 100 mg 7 tablets and 8 tablets and 150 mg 56 tablets. Each box sells for about more than 6,000 yuan. Overseas, the price of each box of the original research version may be as high as about 8,000 US dollars. In addition, there are also generic olaparib drugs in overseas markets, such as the Laos and Bangladeshi versions, whose pharmaceutical ingredients are similar to the original drug. Taking the 50mg112 specification as an example, the price per box is about more than 2,000 yuan.