2024 Pirfenidone/Isri Price List

Pirfenidone/Pirfenidone is a drug used to treat certain types of pulmonary fibrosis, especially idiopathic pulmonary fibrosis (IPF). The mechanism of action of pirfenidone is relatively complex. It mainly slows down the fibrosis process of lung tissue by inhibiting the proliferation of fibroblasts and collagen synthesis. At the same time, it also has anti-inflammatory effects, which can reduce the release of inflammatory mediators and slow down lung damage.

Studies have shown that pirfenidone can interfere with the fibrosis process at the molecular level by regulating cell signaling pathways and inhibiting the activity of the transcription factorTGF-β. In addition, the inhibitory effect of pirfenidone on oxidative stress is also considered to be an important component of its anti-fibrotic effect.

Clinical trial results show that pirfenidone can significantly improve the lung function of patients with idiopathic pulmonary fibrosis, slow down the progression of the disease, and improve the quality of life. Its efficacy and safety have been verified in multiple randomized controlled trials, such as the ASCEND and CAPACITY trials. These studies showed that patients treated with pirfenidone showed significant improvements in vital capacity, distance walking ability, and other physiological measures compared with placebo.

In terms of side effects, common adverse reactions of pirfenidone include digestive tract problems, such as nausea, vomiting, diarrhea, and loss of appetite.

In China, the original drug pirfenidone has been approved for marketing and included in Class B medical insurance, but reimbursement is limited to patients who meet the indications. The price per box of 100 mg and 54 capsules is approximately RMB 500. At the same time, overseas markets such as India also provide generic drugs of pirfenidone. The price of each box of 200mg 30 tablets is about 100 yuan (the price may fluctuate due to exchange rate changes), and the drug ingredients are roughly the same as the original drug.