How long can you live with childhood neuroblastoma?

The survival time of childhood neuroblastoma (Neuroblastoma) depends on many factors such as the stage of the disease, risk stratification, patient age, and treatment effect. Overall, the prognosis of low-risk and intermediate-risk patients is better, while the survival time of high-risk patients is significantly shorter than that of low-risk patients.

1. Low-risk neuroblastoma: Low-risk patients can usually be cured by surgical resection or combined with chemotherapy, and the 5 annual survival rate is as high as 90% or more. Some patients may even experience spontaneous tumor regression, resulting in an excellent prognosis.

2. Intermediate-risk neuroblastoma: Intermediate-risk patients require more intensive treatment, including chemotherapy and surgery, and the cure rate is about70%-90%. Survival time is closely related to the standardization of treatment.

3. High-risk neuroblastoma: High-risk patients have complex conditions and are difficult to treat. Even with multimodal treatment (such as high-dose chemotherapy, autologous stem cell transplantation, radiotherapy, and immunotherapy), the 5annual survival rate is only 40%-50%. Some patients may have shorter survival time due to recurrence or metastasis.

4. Influencing factors

Staging: Patients with early stage (I stage, II stage) have a better prognosis, while patients with late stage (IV stage) have a lower survival rate.

Age:The survival rate of children under 18 months is significantly higher than that of patients 18 months and above.

Molecular features: MYCNgene amplification and chromosomal abnormalities (such as 1p and 11q deletions) generally indicate a worse prognosis.

5. The latest treatment progress: In recent years, immunotherapy and targeted therapy such as anti-GD2 monoclonal antibodies (such asDinutuximab) have significantly improved the survival rate of high-risk patients. Early diagnosis and personalized treatment are key to prolonging survival.

To sum up, the survival time of neuroblastoma varies significantly depending on individual circumstances. Most low-risk patients can survive for a long time, while the prognosis of high-risk patients still needs to be further improved.

(Click to view the introduction of drugs for the treatment of neuroblastoma in children. For specific drug details, please click for one-to-one consultation.)

xa0

ReferenceInformation：https://www.cancer.gov/types/neuroblastoma