Serpatinib dosage and dosage

Serpatinib, as a highly selectiveRET oral inhibitor, is mainly used to treat non-small cell lung cancer and thyroid cancer. Serpatinib is an oral capsule, and its dosage is mainly adjusted based on the patient's weight.

For patients weighing less than50 kg, the recommended dose is 120 mg in two divided doses daily, approximately every 12 hours. For patients weighing 50 kg and above, it is recommended to take 160 mg twice a day, with a dosing interval of about 12 hours. For children aged 2 to less than 12 years old, the dosage is based on body surface area, so it is necessary to strictly follow the doctor's instructions.

Serpatinib should be taken with a full glass of water, making sure the capsule is swallowed whole and avoid chewing, crushing or cutting the capsule.

If vomiting occurs after taking serpatinib, there is no need to take a supplementary dose. Wait until the next scheduled dose before continuing to take it. Extra missed doses should not be taken unless it is more than 6 hours before the next scheduled dose. Serpatinib can be taken with or without food. However, if you are taking other drugs at the same time, such as proton pump inhibitors, H2 receptor antagonists or acid suppressants with local effects, you need to pay special attention to the time interval between taking the drugs.

When used in combination with a proton pump inhibitor, serpatinib should be taken with food. If you are taking an H2 receptor antagonist, you need to take serpatinib 2 hours before or 10 hours after taking the antagonist. For antacids with local action, serpatinib should be taken 2 hours before or 2 hours after.

For patients with severe liver damage, doctors may reduce the dose of serpatinib accordingly. In addition, the elderly and patients with impaired renal function should also be particularly cautious when taking medications, and dosage adjustments should be determined by doctors based on specific circumstances. Before starting to use serpatinib, be sure to consult a professional doctor and strictly follow the doctor's instructions. During the medication period, relevant indicators, such as blood pressure, electrocardiogram, etc., should be monitored regularly to ensure the safety and effectiveness of the medication. If you experience any discomfort or suspected side effects, you should seek medical attention immediately and inform your doctor that you are using serpatinib.

References:

https://www.drugs.com/dosage/selpercatinib.html