How much does a box of 2025 nintedanib cost?

Nintedanib (Nintedanib) contains the active substance nintedanib and is a drug used to treat diseases in adults, including idiopathic pulmonary fibrosis (IPF), which is pan>A disease of unknown cause in which fibrous tissue forms in the lungs; systemic sclerosis-related interstitial lung disease, a disease in which the immune system (the body's natural defenses) is overactive, leading to the production of fibrous tissue and progressive scarring of the lungs; and other progressive chronic fibrosing interstitial lung diseases.

The active substance in nintedanibnintedanib blocks the activity of some enzymes called tyrosine kinases. These enzymes are present in certain receptors on lung cells (such as vascular endothelial growth factor, FGF and PDGF receptors), where they activate several processes related to fibrogenesis. By blocking these enzymes, nintedanib helps reduce the formation of fibrous tissue in the lungs, which helps prevent symptoms of the disease from getting worse.

The original drug of nintedanib has been launched in the domestic market and is sold under the name"nintedanib ethanesulfonate soft capsules (Vegat/OFev)". According to the national medical insurance policy, this drug has been included in Category B medical insurance, but it only covers patients who meet the indications. For non-indicated patients, they need to purchase it at their own expense. Its common packaging includes 100 mg 30 capsules and 150 mg 30 capsules, with a market price of about 4,000 yuan. At the same time, there are also Turkish and Indian versions of nintedanib on the international market, with specifications of 100 mg 60 pills and 150 mg 60 pills. The price per box is about more than 4,000 to 5,000 yuan (the price fluctuates due to exchange rates). In addition, foreign generic drugs are also on the market, with ingredients similar to the original drugs. Manufacturers include India's BDR, Laos ASEAN and Bangladesh's Beacon, etc. The price per box is about 600 yuan (the price may fluctuate due to exchange rates).

Reference materials:https://www.ema.europa.eu/en/medicines/human/EPAR/ofev