What are the side effects of pemetinib?

Pemigatinib (Pemigatinib) is a targeted drug mainly used to treat patients with cholangiocarcinoma with fibroblast growth factor receptor 2 (FGFR2) gene fusion or rearrangement. It exerts anti-tumor effects by specifically inhibiting the activity of FGFR2, thus blocking the growth signaling pathways of tumor cells. However, as a powerful targeted drug, pemetinib may cause a series of side effects during use, and patients need to pay close attention and deal with it.

Possible serious side effects of pemetinib include eye problems, such as eye pain, redness, dryness, puffiness, or watering, and increased sensitivity to light; vision changes, such as blurred vision, seeing dark spots or "floats," or seeing flashes of light; high levels of phosphate in the blood, which may cause muscle cramps, numbness, tingling around the mouth, and other symptoms. If these serious side effects occur, patients should contact their doctor immediately so that prompt measures can be taken to deal with them.

In addition to the serious side effects mentioned above, pemetinib may also cause some common side effects, such as too high or too low phosphate levels in the blood, dry eyes, stomach pain, nausea, vomiting, loss of appetite, diarrhea, constipation, mouth ulcers, dry mouth, joint pain, back pain, feeling tired, fingernail or toenail problems, dry skin, hair loss, and changes in taste. Most of these side effects are mild to moderate and may gradually lessen or disappear as treatment continues. However, patients still need to pay close attention to their condition and communicate with their doctor promptly if they have any discomfort or concerns.

It should be noted that the side effects listed above are not all side effects that may be caused by pemetinib. Patients may also experience other unlisted side effects while using this drug. Therefore, patients must use pemetinib strictly in accordance with the doctor's instructions and undergo regular review and monitoring to ensure the safety and effectiveness of the treatment. If you develop signs of an allergic reaction, such as hives, difficulty breathing, swelling of the face, lips, tongue, or throat, seek emergency medical help immediately.

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Reference link:https://www.drugs.com/mtm/pemigatinib.html