What are the functions and indications of obeticholic acid tablets?

Obeticholic acid is an important drug mainly used to treat primary biliary cholangitis (PBC), especially in patients who have not responded well to ursodeoxycholic acid (UDCA) therapy. PBC is a chronic liver disease that usually manifests as damage to the hepatic bile ducts and accompanying cholestasis, which may lead to progressive deterioration of liver function and even cirrhosis. Therefore, correct and effective treatment options are crucial to improve patients' quality of life and delay disease progression.

As a legally prescribed drug, obeticholic acid must be used under the guidance and supervision of a doctor. The drug can be used alone or in combination with UDCA to enhance the therapeutic effect. Obeticholic acid provides a viable alternative for patients who are already receiving UDCA but are not responding effectively. In addition, obeticholic acid also shows good therapeutic potential in patients with compensated cirrhosis but without portal hypertension.

Before starting to use obeticholic acid, doctors will carefully evaluate the patient's condition to ensure that there is no decompensated cirrhosis or other serious liver complications, such as ascites or esophageal varices caused by portal hypertension. These conditions may affect the safety and effectiveness of the medication and require special attention.

The dose of obeticholic acid varies depending on individual differences. The usual dose for adults at the initial stage of treatment is 5 mg per day. After three consecutive months, the doctor may adjust the dose based on the patient's tolerance and efficacy, but the dose will not exceed 10 mg per day. The medication and dosage for pediatric patients must be determined by doctors based on specific circumstances, which highlights the individualization and professionalism of the use of this drug.

Reference materials:https://www.mayoclinic.org/drugs-supplements/obeticholic-acid-oral-route/description/drg-20312281