What are the storage requirements for Serputinib/Serpatinib?

Selpercatinib is a highly selective RET kinase inhibitor, mainly used for the treatment of RET fusion-positive non-small cell lung cancer (NSCLC), thyroid cancer and some RET mutant medullary thyroid cancers. As a targeted anti-cancer drug, it has strict storage and preservation requirements in clinical use, which is a key link to ensure the efficacy and safety of the drug.

Usually, seputinib is supplied in the form of capsule preparations, and its storage temperature requirements are relatively clear, and it needs to be stored at a constant room temperature of 20°C to 25°C. The US Pharmacopoeia allows a certain temperature fluctuation, that is, short-term fluctuations between 15°C and 30°C are acceptable, which also provides relative flexibility for daily transportation and temporary storage.

However, the molecular structure of targeted drugs is usually complex and sensitive to environmental factors. If the recommended temperature range is exceeded for a long time, the stability of the drug may decrease or even the active ingredients may decompose, thus affecting the efficacy. Especially during summer transportation or in hot southern regions, if there is no cold chain protection, the drug may lose some of its activity. Therefore, patients should avoid placing them in direct sunlight when storing them at home, and they should not store them in humid bathrooms and other environments to prevent the capsules from getting damp and deteriorating.

The instructions also emphasize the importance of storage in the original packaging, because the packaging bottle or blister is moisture-proof and light-proof, which can ensure the stability of the drug to the greatest extent. Another point worth paying attention to is that seputinib is a high-priced targeted drug that often requires patients to take it regularly for a long time to obtain the best effect. Therefore, waste caused by improper storage not only brings economic losses, but also may affect the continuity of treatment.

Patients should keep the medicine out of the reach of children and pets, use it strictly in accordance with the physician's instructions, and avoid dispensing the medicine by yourself or long-term exposure to the air. As drugs are gradually included in the medical insurance of various countries, how to standardize storage and reduce losses has become an important part of clinical management.

Reference:https://en.wikipedia.org/wiki/Selpercatinib