One month’s treatment cost of Sotolaxib (AMG 510) and price comparison of different versions

Sotorasib is an oral small molecule KRAS G12C inhibitor, mainly used to treat KRAS G12C mutation-positive non-small cell lung cancer (NSCLC) patients. The drug can directly inhibit the KRAS mutated protein and block tumor signaling pathways, thereby slowing down tumor progression. It is worth noting that sotoracib is not yet available in China, so domestic patients cannot purchase it directly through hospitals or pharmacies and can only obtain it through formal overseas channels.

In overseas markets, the original drug of sotorasibu is mainly divided into European version and Hong Kong version, which are quite expensive. Taking the European version as an example, each box is generally 120mg*240 tablets, and the monthly dosage is about one box. Its price is usually in the range of tens of thousands of RMB, depending on the channel and region. Original drugs have higher research and development costs and patent protection, so the cost imposes a greater financial burden on patients.

Compared with the original drug, the price of the generic drug Sotorasibu that has been launched overseas is more affordable. For example, the price of generic drugs produced by two companies, Lucius and Daxiong, in the Laotian market is only more than 1,000 yuan for 120mg*56 tablets. 4 boxes are required per month, which significantly reduces the cost of medication for patients. The ingredients of generic drugs are basically the same as those of original drugs, which can reduce financial pressure on patients while ensuring efficacy. They are currently a commonly used alternative for overseas patients.

To sum up, the cost of one month's treatment with sotorasibu varies greatly overseas depending on the version: the original drug may cost tens of thousands of yuan, while the generic drug only costs a few thousand yuan or even less. For domestic patients, if they really need to use this drug, they can consider overseas generic drug plans and use it under the guidance of professional doctors. At the same time, patients should pay attention to drug safety and formal purchasing channels, and avoid illegal channels to ensure efficacy and drug safety.

Reference link:https://www.drugs.com