Where to buy Mitotane in China

Mitotane (Mitotane) is a specific adrenocortical inhibitor that also has cytotoxic effects on adrenocortical tumors. It is the core drug for the treatment of adrenocortical cancer (Adrenocortical Carcinoma, ACC; Adrenal Cancer ) . ACC is a rare and highly malignant endocrine tumor that progresses rapidly and has a high recurrence rate. Mitotane is indispensable for postoperative adjuvant therapy and advanced disease management. Its mechanism of action not only directly destroys adrenal tumor cells, but also inhibits the synthesis of corticosteroids, thereby alleviating symptoms caused by excessive hormones in patients, such as hypertension, hypokalemia and abnormal glucose tolerance.

Clinically, mitotane can be used for postoperative adjuvant therapy, especially for patients with incomplete tumor resection or high risk of recurrence. It is also the drug of choice for unresectable or recurrent or metastatic ACC.ACC. Long-term use of mitotane can delay disease progression and improve patients' quality of life to a certain extent. Its treatment characteristics are chronic, long-term, and individualized dose adjustment. Therefore, blood drug concentration and liver and kidney function indicators need to be regularly monitored during use to ensure efficacy and safety.

In China, the original drug mitotane has been approved for marketing, but it has not yet been included in the medical insurance system. The common specifications in China are 500mg*100 tablets/box, and the price is about more than 9,000 yuan. Since mitotane is a scarce anti-tumor drug, its drug purchase channels are mainly concentrated in large tertiary hospitals, designated distributors of some imported drugs and hospital pharmacies. Patients need to strictly abide by the prescription management regulations when purchasing and using it, and complete dosage adjustments and blood drug monitoring under the guidance of professional doctors.

It is worth noting that mitotane is a slow-acting drug, and its blood concentration accumulates slowly, so the onset of effect may be longer. Patients and their families need to be patient during use and strictly follow the doctor's instructions for follow-up visits and blood drug monitoring. At the same time, combined with a healthy diet, moderate exercise and regular work and rest, drug tolerance can be improved to a certain extent.

Reference materials:https://go.drugbank.com/drugs/DB00648